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Detubularization of the bowel segment and cross-folding into a sphere forms the maximum capacity reservoir for a given bowel segmentand limits the ability of the bowel segment to develop a coordinated and synchronousperistalsis.6 The spherical configuration maximizes the radius of the reservoir, whichaccording to Laplace law (pressure = tension/radius) will translate into lower filling andstorage pressures. Cases of RAeB-1 aredefined by 5–9% blasts in the bone marrow.

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